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Pfizer also said that acceptance of total impurities in drug substances or total degradation products in drug products should take into account the process and product knowledge, as well as the acceptance criteria for individual impurities

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The mechanisms involved included reduced autophagy flux impairment and inhibition of apoptosis

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A patient who lost weight but developed fatigue, constipation, under-eating, or muscle weakness may need a different strategy than a patient who lost weight steadily, maintained strength, and improved lab markers

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